‘Pronouns in Bio’ meme: what will we learn?

What’s in a meme? Well this one seems to have something to say about pronouns and biology. But your mileage may vary.

When I first saw this meme on a Discord server, I asked the person who posted it to explain it like I’m five. They hadn’t created the meme themselves, but I thought they might be able to offer some hints about how to interpret it.